Different spectrophotometric methods for simultaneous quantitation of Vericiguat and its alkaline degradation product: a comparative study with greenness profile assessment.

ABSTRACT: Investigations concerning novel drugs and their induced degradation products are necessary for clinical research and quality control in the pharmaceutical industry. Four spectrophotometric techniques have been performed for simultaneous quantitation of Vericiguat (VER) and its alkali-induced degradation product (ADP) without prior separation. Method A is a dual wavelength method (DW) that estimates the absorbance difference at 314-328 nm, and 246-262 nm for VER and ADP; respectively. Method B uses a ratio difference method (RD) to estimate the ratio spectrum's amplitude difference (DP_318-342) and (DP_284-292) for VER and ADP; respectively. Method C uses a first derivative ratio method (¹DD) to estimate the peak ratio spectrum amplitude of the first derivativ

SUBMITTER: Mustafa DM 

PROVIDER: S-EPMC10754859 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature