Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels.

ABSTRACT: Large amounts of net electrical charge are known to accumulate on inhaled aerosols during their generation using commonly-available inhalers. This effect often leads to superfluous deposition in the extra-thoracic airways at the cost of more efficient inhalation therapy. Since the electrostatic force is inversely proportional to the square of the distance between an aerosol and the airway wall, its role has long been recognized as potentially significant in the deep lungs. Yet, with the complexity of exploring such phenomenon directly at the acinar scales, in vitro experiments have been largely limited to upper airways models. Here, we devise a microfluidic alveolated airway channel coated with conductive material to quantify in vitro the significance of electrostatic effects on inhaled ae

SUBMITTER: Bessler R 

PROVIDER: S-EPMC10754925 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature