Molecular and clinical aspects relevant for counseling individuals with clonal hematopoiesis of indeterminate potential.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) has fascinated the medical community for some time. Discovered about a decade ago, this phenomenon links age-related alterations in hematopoiesis not only to the later development of hematological malignancies but also to an increased risk of early-onset cardiovascular disease and some other disorders. CHIP is detected in the blood and is characterized by clonally expanded somatic mutations in cancer-associated genes, predisposing to the development of hematologic neoplasms such as MDS and AML. CHIP-associated mutations often involve DNA damage repair genes and are frequently observed following prior cytotoxic cancer therapy. Genetic predisposition seems to be a contributing factor. It came as a surprise that CHIP significantly elevate

SUBMITTER: Cacic AM 

PROVIDER: S-EPMC10754976 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature