Scaffold-induced compression enhances ligamentization potential of decellularized tendon graft reseeded with ACL-derived cells.

ABSTRACT: Anterior cruciate ligament (ACL) reconstruction is often performed using a tendon graft. However, the predominant synthesis of fibrotic scar tissue (type III collagen) occurs during the healing process of the tendon graft, resulting in a significantly lower mechanical strength than that of normal ACL tissue. In this study, ACL-derived cells were reseeded to the tendon graft, and scaffold-induced compression was applied to test whether the compressive force results in superior cell survival and integration. Given nanofiber polycaprolactone (PCL) scaffold-induced compression, ACL-derived cells reseeded to a tendon graft demonstrated superior cell survival and integration and resulted in higher gene expression levels of type I collagen compared to non-compressed cell-allograft composites i

SUBMITTER: Park J 

PROVIDER: S-EPMC10755058 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature