Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity.

ABSTRACT:

Objectives

Pediatric acute respiratory distress syndrome (PARDS) is a source of substantial morbidity and mortality in the PICU, and different plasma biomarkers have identified different PARDS and ARDS subgroups. We have a poor understanding of how these biomarkers change over time and with changing lung injuries. We sought to determine how biomarker levels change over PARDS course, whether they are correlated, and whether they are different in critically ill non-PARDS patients.

Design

Two-center prospective observational study.

Setting

Two quaternary care academic children's hospitals.

Patients

Subjects under 18 years of age admitted to the PICU who were intubated and met the Second Pediatric Acute Lung Injury Consensus Conference-2 PARDS diagnostic criteria a

SUBMITTER: Williams JG 

PROVIDER: S-EPMC10755079 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature