Mouse models of diabetes-related ulcers: a systematic review and network meta-analysis.

ABSTRACT:

Background

Diabetic foot ulcers (DFUs) are a common complication of diabetes, associated with important morbidity. Appropriate animal models of DFUs may improve drug development, and subsequently the success rate of clinical trials. However, while many models have been proposed, they are extremely heterogeneous, and no standard has emerged. We thus propose a systematic review with a network meta-analysis (NMA) to gather direct and indirect evidence, and compare the different mouse models of diabetes-related ulcers.

Methods

The systematic search was performed in Pubmed and Embase. The main outcomes were wound size measurement at days 3, 7, 11 and 15 (±1 day). The risk of bias and methodological quality of all included studies was assessed by using the Systematic Review Center

SUBMITTER: Couturier A 

PROVIDER: S-EPMC10755106 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature