SARS-CoV-2 convalescence and hybrid immunity elicits mucosal immune responses.

ABSTRACT:

Background

Mucosal antibodies play a key role in the protection against SARS-CoV-2 infection in the upper respiratory tract, and potentially in limiting virus replication and therefore onward transmission. While systemic immunity to SARS-CoV-2 is well understood, we have a limited understanding about the antibodies present on the nasal mucosal surfaces.

Methods

In this study, we evaluated SARS-CoV-2 mucosal antibodies following previous infection, vaccination, or a combination of both. Paired nasal fluid and serum samples were collected from 143 individuals, which include convalescent, vaccinated, or breakthrough infections.

Findings

We detected a high correlation between IgG responses in serum and nasal fluids, which were higher in both compartments in vaccinated com

SUBMITTER: Puhach O 

PROVIDER: S-EPMC10755109 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature