Determinants of persistent symptoms after treatment for Lyme borreliosis: a prospective observational cohort study.

ABSTRACT:

Background

Patients treated for Lyme borreliosis (LB) frequently report persistent symptoms. Little is known about risk factors and etiology.

Methods

In a prospective observational cohort study with a follow-up of one year, we assessed a range of microbiological, immunological, genetic, clinical, functional, epidemiological, psychosocial and cognitive-behavioral variables as determinants of persistent symptoms after treatment for LB. Between 2015 and 2018 we included 1135 physician-confirmed LB patients at initiation of antibiotic therapy, through clinical LB centers and online self-registration. Two reference cohorts of individuals without LB (n = 4000 and n = 2405) served as a control. Prediction analyses and association studies were used to identify determinants, as colle

SUBMITTER: Vrijmoeth HD 

PROVIDER: S-EPMC10755112 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature