Prenatal diagnosis of isolated bilateral clubfoot: Is amniocentesis indicated?

ABSTRACT:

Introduction

The aim of this study is to evaluate the benefit of cytogenetic testing by amniocentesis after an ultrasound diagnosis of isolated bilateral talipes equinovarus.

Material and methods

This multicenter observational retrospective study includes all prenatally diagnosed cases of isolated bilateral talipes equinovarus in five fetal medicine centers from 2012 through 2021. Ultrasound data, amniocentesis results, biochemical analyses of amniotic fluid and parental blood samples to test neuromuscular diseases, pregnancy outcomes, and postnatal outcomes were collected for each patient.

Results

In all, 214 fetuses with isolated bilateral talipes equinovarus were analyzed. A first-degree family history of talipes equinovarus existed in 9.8% (21/214) of our cohort.

SUBMITTER: Leyne E 

PROVIDER: S-EPMC10755119 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature