Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero.

ABSTRACT:

Introduction

Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born to women with PCOS. We also investigated whether the effect of metformin on birth anthropometrics is modified by maternal pre-pregnancy body mass index, PCOS hyperandrogenic phenotype, serum androgen levels, preconception use of metformin and offspring sex. Additionally, we assessed newborn anthropometrics in relation to a national reference population.

Material and methods

Individual data from three randomized controlled triasl were pooled. The randomized controlled trials investigated the effects of metformin in pregnant women with PCOS. In all, 397 and 403

SUBMITTER: Nilsen GO 

PROVIDER: S-EPMC10755130 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature