Time trends in human papillomavirus prevalence and genotype distribution in vulvar carcinoma in Norway.

ABSTRACT:

Introduction

Approximately 25%-43% of all vulvar carcinomas are associated with human papillomavirus (HPV). In many countries, vulvar carcinoma incidence rates are increasing, possibly due to greater HPV exposure. However, studies exploring changes in HPV prevalence and genotype distribution in vulvar carcinoma over time are scarce. Our aim was to evaluate time trends in HPV prevalence and genotype distribution in vulvar squamous cell carcinoma in an unselected, nationwide sample of Norwegian women. Further, we explored clinical and histopathological aspects in relation to HPV status and investigated whether HPV status was associated with survival.

Material and methods

All vulvar squamous cell carcinoma cases from 1970-1975 and 2000-2005 were extracted from the Cancer Regist

SUBMITTER: Meltzer-Gunnes CJ 

PROVIDER: S-EPMC10755140 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature