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Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks.

ABSTRACT: Two independent temporal-spatial clusters of hospital-onset Rhizopus infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial Rhizopus outbreaks.

SUBMITTER: Chu VT 

PROVIDER: S-EPMC10755156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Two independent temporal-spatial clusters of hospital-onset <i>Rhizopus</i> infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial <i>Rhizopus</i> outbreaks. ...[more]

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