Social isolation from childhood to mid-adulthood: is there an association with older brain age?

ABSTRACT:

Background

Older brain age - as estimated from structural MRI data - is known to be associated with detrimental mental and physical health outcomes in older adults. Social isolation, which has similar detrimental effects on health, may be associated with accelerated brain aging though little is known about how different trajectories of social isolation across the life course moderate this association. We examined the associations between social isolation trajectories from age 5 to age 38 and brain age assessed at age 45.

Methods

We previously created a typology of social isolation based on onset during the life course and persistence into adulthood, using group-based trajectory analysis of longitudinal data from a New Zealand birth cohort. The typology comprises four groups:

SUBMITTER: Lay-Yee R 

PROVIDER: S-EPMC10755222 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature