Predictors of diagnostic conversion from major depression to bipolar disorder: a Swedish national longitudinal study.

ABSTRACT:

Background

It is clinically important to predict the conversion of major depression (MD) to bipolar disorder (BD). Therefore, we sought to identify related conversion rates and risk factors.

Methods

This cohort study included the Swedish population born from 1941 onward. Data were collected from Swedish population-based registers. Potential risk factors, including family genetic risk scores (FGRS), which were calculated based on the phenotypes of relatives in the extended family and not molecular data, and demographic/clinical characteristics from these registers were retrieved. Those with first MD registrations from 2006 were followed up until 2018. The conversion rate to BD and related risk factors were analyzed using Cox proportional hazards models. Additional analyses we

SUBMITTER: Rhee SJ 

PROVIDER: S-EPMC10755232 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature