The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis.

ABSTRACT:

Background

Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific.

Methods

A total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men: n = 218; women: n = 84). Total trauma score and trauma subtypes were assessed using the Childhood Trauma

SUBMITTER: Enthoven AD 

PROVIDER: S-EPMC10755234 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature