Associations between polygenic risk scores and accelerated brain ageing in smokers.

ABSTRACT:

Background

Smoking contributes to a variety of neurodegenerative diseases and neurobiological abnormalities, suggesting that smoking is associated with accelerated brain aging. However, the neurobiological mechanisms affected by smoking, and whether they are genetically influenced, remain to be investigated.

Methods

Using structural magnetic resonance imaging data from the UK Biobank (n = 33 293), a brain age predictor was trained on non-smoking healthy groups and tested on smokers to obtain the BrainAge Gap (BAG). The cumulative effect of multiple common genetic variants associated with smoking was then calculated to acquire a polygenic risk score (PRS). The relationship between PRS, BAG, total gray matter volume (tGMV), and smoking parameters was explored and furthe

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10755245 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature