Cerium oxide nanoparticles modulating the Parkinson's disease conditions: From the alpha synuclein structural point of view and antioxidant properties of cerium oxide nanoparticles.

ABSTRACT: Parkinson's and Alzheimer's disease is the main cause of dementia, which is associated with the progressive deterioration of the intelligence and senses. Free radicals are created during oxidative stress in cells, which are considered one of the destructive factors in neurodegenerative diseases. In this study, the antifibrillar and antioxidant properties of cerium oxide nanoparticles (CeO₂ NPs) were investigated experimentally and theoretically. The CeO₂ NPs were synthesized and analyzed to reveal the physicochemical and biological properties. The results showed that the CeO₂ NPs have unique properties with potent antioxidant activities. The experimental and computational studies showed that the CeO₂ NPs interact with the active site of Alpha-syn

SUBMITTER: Yao X 

PROVIDER: S-EPMC10755285 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature