A ROI-based quantitative pipeline for ¹⁸F-FDG PET metabolism and pCASL perfusion joint analysis: Validation of the ¹⁸F-FDG PET line.

ABSTRACT: In Mild Cognitive Impairment (MCI), the study of brain metabolism, provided by 18F-FluoroDeoxyGlucose Positron Emission Tomography (¹⁸F-FDG PET) can be integrated with brain perfusion through pseudo-Continuous Arterial Spin Labeling Magnetic Resonance sequences (MR pCASL). Cortical hypometabolism identification generally relies on wide control group datasets; pCASL control groups are instead not publicly available yet, due to lack of standardization in the acquisition parameters. This study presents a quantitative pipeline to be applied to PET and pCASL data to coherently analyze metabolism and perfusion inside 16 matching cortical regions of interest (ROIs) derived from the AAL3 atlas. The PET line is tuned on 36 MCI patients and 107 healthy control subjects, to agree in identi

SUBMITTER: Cerina V 

PROVIDER: S-EPMC10755331 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature