Does surgery affect systemic immune response? a perioperative analysis of TGF-β, IL-8 and CD45RO.

ABSTRACT:

Background

The options of (neo-)adjuvant immunotherapy in addition to surgery in the treatment of oral squamous cell carcinoma (OSCC) are steadily increasing, but patients do not always respond to therapy as intended. The objectives of this study were to investigate the systemic perioperative course of the biomarkers CD45RO, TGF-β, and IL-8 in non-tumor-related minor and tumor-related major maxillofacial surgery and to perform association analyses with demographic and histomorphologic parameters. A deeper understanding of surgery-related changes in various of different immune biomarkers could help to better understand the immunologic consequences of surgery which could influence immunotherapeutic protocols.

Methods

Peripheral whole blood from 38 patients was analyzed by real

SUBMITTER: Trumet L 

PROVIDER: S-EPMC10755470 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature