Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.

ABSTRACT:

Objective

Lipoprotein assembly and secretion in the small intestine are critical for dietary fat absorption. Surfeit locus protein 4 (SURF4) serves as a cargo receptor, facilitating the cellular transport of multiple proteins and mediating hepatic lipid secretion in vivo. However, its involvement in intestinal lipid secretion is not fully understood. In this study, we investigated the role of SURF4 in intestinal lipid absorption.

Methods

We generated intestine-specific Surf4 knockout mice and characterized the phenotypes. Additionally, we investigated the underlying mechanisms of SURF4 in intestinal lipid secretion using proteomics and cellular models.

Results

We unveiled that SURF4 is indispensable for apolipoprotein transport and lipoprotein secretion. Intestine-spe

SUBMITTER: Guo CG 

PROVIDER: S-EPMC10755498 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature