Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia.

ABSTRACT:

Background

Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia. GABA interneuron deficiency is locally expressed in the form of neural activity desynchronization. We mapped the functional anatomy of local synchrony in the cerebral cortex in schizophrenia using functional connectivity MRI.

Methods

Data from 86 patients with schizophrenia and 137 control subjects were obtained from publicly available repositories. Resting-state functional connectivity maps based on Iso-Distant Average Correlation measures across three distances were estimated detailing the local functional structure of the cerebral

SUBMITTER: Pujol J 

PROVIDER: S-EPMC10755567 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature