The link between obesity and insulin resistance among children: Effects of key metabolites.

ABSTRACT:

Background

Childhood obesity became a severe public health challenge, and insulin resistance (IR) was one of the common complications. Both obesity and IR were considered as the basis of metabolic disorders. However, it is unclear which common key metabolites are associated with childhood obesity and IR.

Methods

The children were divided into normal weight and overweight/obese groups. Fasting blood glucose and fasting insulin were measured, and homeostasis model assessment of insulin resistance was calculated. Liquid chromatography-tandem mass spectrometry was applied for metabonomic analysis. Multiple linear regression analysis and correlation analysis explored the relationships between obesity, IR, and metabolites. Random forests were used to rank the importance of differe

SUBMITTER: Yan W 

PROVIDER: S-EPMC10755598 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature