Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.

ABSTRACT: The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells. We addressed the function of the inositol-requiring enzyme 1 (IRE1) signaling branch of the UPR in NK cells in homeostasis and microbial challenge. Cell-intrinsic compound deficiency of IRE1 and its downstream transcription factor XBP1 in NKp46⁺ NK cells, did not affect basal NK cell homeostasis, or overall outcome of viral MCMV infection. However, mixed bone marrow chimeras revealed a competitive advantage in the proliferation of IRE1-sufficient Ly49H⁺ NK cells after viral infection. CITE-Seq analysis confirmed strong inducti

SUBMITTER: Vetters J 

PROVIDER: S-EPMC10755724 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature