Functionalized biomimetic mineralized collagen promotes osseointegration of 3D-printed titanium alloy microporous interface.

ABSTRACT: Mineralized collagen (MC) is the fundamental unit of natural bone tissue and can induce bone regeneration. Unmodified MC has poor mechanical properties and a single component, making it unable to cope with complex physiological environment. In this study, we introduced sodium alginate (SA) and vascular endothelial growth factor (VEGF) into the MC material to construct functionalized mineralized collagen (FMC) with good mechanical strength and the ability to continuously release growth factors. The FMC is filled into the pores of 3D printed titanium alloy scaffold to form a new organic-inorganic bioactive interface. With the continuous degradation of FMC, bone marrow mesenchymal stem cells (BMSCs) and vascular endothelial cells (VECs) in the surrounding environment are recruited to the surf

SUBMITTER: Sheng X 

PROVIDER: S-EPMC10755784 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature