Evaluation of phenobarbital dosing strategies for hospitalized patients with alcohol withdrawal syndrome.

ABSTRACT:

Objective

Alcohol remains the fourth‑leading preventable cause of death in the U.S. The objective of this study was to compare the incidence of phenobarbital (PHB)-resistant withdrawal and determine risk factors for PHB-resistant alcohol withdrawal syndrome (AWS).

Methods

This retrospective cohort study included adults admitted to an academic center with AWS who received PHB as part of an institution-specific treatment protocol. The primary outcome was incidence of AWS resistant to initial protocolized PHB load across two cohorts (standard-dose, 10 mg/kg vs. low-dose, 6 mg/kg).

Results

Among 176 included patients, there was no difference in the incidence of PHB-resistant AWS based on initial PHB load [low-dose load, 21 (18.3%) vs. standard-dose load, 12 (19.7%), p = 0

SUBMITTER: Stallworth S 

PROVIDER: S-EPMC10755809 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature