Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients.

ABSTRACT:

Background

Passive immunization with plasma collected from convalescent patients has been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available regarding the use of convalescent plasma in patients with Covid-19-induced acute respiratory distress syndrome (ARDS).

Methods

In this open-label trial, we randomly assigned adult patients with Covid-19-induced ARDS who had been receiving invasive mechanical ventilation for less than 5 days in a 1:1 ratio to receive either convalescent plasma with a neutralizing antibody titer of at least 1:320 or standard care alone. Randomization was stratified according to the time from tracheal intubation to inclusion. The primary outcome was death by day 28.

Results

A total of 475 patients underwent rando

SUBMITTER: Misset B 

PROVIDER: S-EPMC10755833 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature