Primary biliary cirrhosis and osteoporosis: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have identified a heightened risk of osteoporosis and fractures in patients with primary biliary cholangitis (PBC). However, conclusive evidence establishing a causal relationship between the two, and a clear mechanism explaining this association, remains elusive.

Methods

We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between PBC and osteoporosis. This analysis utilized five MR methods: inverse-variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode. Sensitivity analyses were performed, employing various models and testing methods, to assess the impact of heterogeneity and pleiotropy on the results and to confirm their robustness.

Results

A

SUBMITTER: Zhao D 

PROVIDER: S-EPMC10755900 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature