Gray-white matter boundary Z-score and volume as imaging biomarkers of Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) presents typically gray matter atrophy and white matter abnormalities in neuroimaging, suggesting that the gray-white matter boundary could be altered in individuals with AD. The purpose of this study was to explore differences of gray-white matter boundary Z-score (gwBZ) and its tissue volume (gwBTV) between patients with AD, amnestic mild cognitive impairment (MCI), and cognitively normal (CN) elderly participants.

Methods

Three-dimensional T1-weight images of a total of 227 participants were prospectively obtained from our institute from 2006 to 2022 to map gwBZ and gwBTV on images. Statistical analyses of gwBZ and gwBTV were performed to compare the three groups (AD, MCI, CN), to assess their correlations with age and Korean version

SUBMITTER: Tian Y 

PROVIDER: S-EPMC10755914 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature