Obesity, birth weight, and lifestyle factors for frailty: a Mendelian randomization study.

ABSTRACT: Obesity, birth weight and lifestyle factors have been found associated with the risk of frailty in observational studies, but whether these associations are causal is uncertain. We conducted a two-sample Mendelian randomization study to investigate the associations. Genetic instruments associated with the exposures at the genome-wide significance level (p < 5 × 10^-8) were selected from corresponding genome-wide association studies (n = 143,677 to 703,901 individuals). Summary-level data for the frailty index were obtained from the UK Biobank (n = 164,610) and Swedish TwinGene (n = 10,616). The β of the frailty index was 0.15 (p = 3.88 × 10^-9) for 1 standard deviation increase in the prevalence of smoking initiation, 0.19 (p =

SUBMITTER: Gu Y 

PROVIDER: S-EPMC10756094 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature