Association of modifiable risk factors with obstructive sleep apnea: a Mendelian randomization study.

ABSTRACT:

Background

The risk factors involved in obstructive sleep apnea (OSA) have not been clearly identified yet. We attempted to systematically investigate genetically predicted modifiable risk factors and lifestyle behaviors associated with OSA.

Methods

The association between 34 risk factors and OSA was evaluated using the two-sample Mendelian randomization (MR). Genetic variants for risk factors were acquired from European-descent genome-wide studies. Data sources for OSA were extracted from FinnGen study with 16,761 cases and 201,194 controls. The primary analysis chosen was the inverse-variance weighted method.

Results

MR analyses provide evidence of genetically predicted poor overall health rating (odds ratio (OR), 2.82; 95% confidence interval (CI), 1.95-4.08), nap

SUBMITTER: Li Y 

PROVIDER: S-EPMC10756101 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature