A glycosylation-related signature predicts survival in pancreatic cancer.

ABSTRACT:

Background

Tumor initiation and progression are closely associated with glycosylation. However, glycosylated molecules have not been the subject of extensive studies as prognostic markers for pancreatic cancer. The objectives of this study were to identify glycosylation-related genes in pancreatic cancer and use them to construct reliable prognostic models.

Materials and methods

The Cancer Genome Atlas and Gene Expression Omnibus databases were used to assess the differential expression of glycosylation-related genes; four clusters were identified based on consistent clustering analysis. Kaplan-Meier analyses identified three glycosylation-related genes associated with overall survival. LASSO analysis was then performed on The Cancer Genome Atlas and International Cancer Gen

SUBMITTER: Hu H 

PROVIDER: S-EPMC10756102 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature