Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China.

ABSTRACT:

Background

Xuanwei lung cancer (XWLC) is well-known for its high incidence and mortality. However, the molecular mechanism is still unclear.

Methods

We performed a comprehensive transcriptomic, proteomic, and phosphoproteomic characterization of tumors and matched normal adjacent tissues from three XWLC patients with lung adenocarcinoma (LUAD).

Results

Integrated transcriptome and proteome analysis revealed dysregulated molecules and pathways in tumors and identified enhanced metabolic-disease coupling. Non-coding RNAs were widely involved in post-transcriptional regulatory mechanisms to coordinate the progress of LUAD and partially explained the molecular differences between RNA and protein expression patterns. Phosphoproteome provided evidence support for new phosph

SUBMITTER: Jiang B 

PROVIDER: S-EPMC10756121 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature