Examining the role of dopamine in methylphenidate's effects on resting brain function.

ABSTRACT: The amplitude of low-frequency fluctuations (ALFF) and global functional connectivity density (gFCD) are fMRI (Functional MRI) metrics widely used to assess resting brain function. However, their differential sensitivity to stimulant-induced dopamine (DA) increases, including the rate of DA rise and the relationship between them, have not been investigated. Here we used, simultaneous PET-fMRI to examine the association between dynamic changes in striatal DA and brain activity as assessed by ALFF and gFCD, following placebo, intravenous (IV), or oral methylphenidate (MP) administration, using a within-subject double-blind placebo-controlled design. In putamen, MP significantly reduced D_2/3 receptor availability and strongly reduced ALFF and increased gFCD in the brain for IV-MP (

SUBMITTER: Tomasi D 

PROVIDER: S-EPMC10756194 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature