A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons.

ABSTRACT: Coordination of cellular responses to stress is essential for health across the lifespan. The transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing environments and cellular dysfunction, but constitutive activation of SKN-1 drives premature aging thus revealing the importance of turning off cytoprotective pathways. Here, we identify how SKN-1 activation in two ciliated ASI neurons in Caenorhabditis elegans results in an increase in organismal transcriptional capacity that drives pleiotropic outcomes in peripheral tissues. An increase in the expression of established SKN-1 stress response and lipid metabolism gene classes of RNA in the ASI neurons, in addition to the increased expression of several classes of noncoding RNA, define a molecular

SUBMITTER: Turner CD 

PROVIDER: S-EPMC10756303 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature