Increased cortical inhibition following brief motor memory reactivation supports reconsolidation and overnight offline learning gains.

ABSTRACT: Practicing motor skills stabilizes and strengthens motor memories by repeatedly reactivating and reconsolidating them. The conventional view, by which a repetitive practice is required for substantially improving skill performance, has been recently challenged by behavioral experiments, in which even brief reactivations of the motor memory have led to significant improvements in skill performance. However, the mechanisms which facilitate brief reactivation-induced skill improvements remain elusive. While initial memory consolidation has been repeatedly associated with increased neural excitation and disinhibition, reconsolidation has been shown to involve a poorly understood mixture of both excitatory and inhibitory alterations. Here, we followed a 3-d reactivation-reconsolidation framewor

SUBMITTER: Eisenstein T 

PROVIDER: S-EPMC10756311 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature