Genetic association and bidirectional Mendelian randomization for causality between gut microbiota and six lung diseases.

ABSTRACT:

Purposes

Increasing evidence suggests that intestinal microbiota correlates with the pathological processes of many lung diseases. This study aimed to investigate the causality of gut microbiota and lung diseases.

Methods

Genetic information on intestinal flora and lung diseases [asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), lower respiratory tract infection (LRTI), pulmonary arterial hypertension (PAH)] and lung function was obtained from UK Biobank, FinnGen, and additional studies. A Mendelian randomization (MR) analysis was conducted to explore the causal association between gut microbiota and lung diseases.

Results

The genetic liability to lung diseases may be associated with the abundance of certain mic

SUBMITTER: Su Y 

PROVIDER: S-EPMC10756341 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature