The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Helicobacter Pylori Infection to Gastric Cancer.

ABSTRACT:

Background/aim

Elevated serum interleukin-16 (IL-16) levels have been reported in gastric cancer (GC) tissues; however, the role of IL-16 genotypes in GC susceptibility remains largely unexplored. This study aimed to investigate the contribution of IL-16 genotypes to GC susceptibility and to assess their interactions with smoking, alcohol drinking, and Helicobacter pylori (H. pylori) infection.

Materials and methods

Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology was employed to determine IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics in 161 patients with GC and 483 controls.

Results

Significant differences were observed in the distribution of genotypic (p=0.0009) and allelic (p=0.0002) frequencies

SUBMITTER: Fu CK 

PROVIDER: S-EPMC10756437 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature