Association of Matrix Metalloproteinase-1 Promoter Polymorphisms With Asthma Risk.

ABSTRACT:

Background/aim

Matrix metalloproteinase-1 (MMP-1) expression has been documented as an influential contributor to the intricate milieu of allergic airway inflammation, tissue remodeling, and the exacerbation of asthma's severity. However, the genetic role underlying MMP-1 in the context of asthma has remained enigmatic, with its full implications yet to be unveiled. Considering this, our research was designed to investigate the association of MMP-1 -1607 rs1799750 and the propensity for asthma severity.

Patients and methods

As a case-control investigation, our study enrolled 198 individuals diagnosed with asthma and age- and sex-matched 453 non-asthmatic controls. The genotypes of MMP-1 rs1799750 were determined utilizing the polymerase chain reaction-restriction fragment le

SUBMITTER: Chen LH 

PROVIDER: S-EPMC10756462 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature