Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause.

ABSTRACT:

Background/aim

Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy.

Patients and methods

Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay.

Results

KLHL11-antibody was found in three of 168 control patients with paraneoplastic neurological disorders and four pediatric patients (4-8-year-old, 2 boys/2 girls) with seizures of unknown cause presenting with myoclonic-atonic epilepsy, generalized epilepsy or childhood epilepsy with centrotemporal spikes. In these four cases, seizures continued for 2-7 months, responded

SUBMITTER: Tzartos J 

PROVIDER: S-EPMC10756464 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature