Review and standard operating procedures for collection of biospecimens and analysis of biomarkers in new onset refractory status epilepticus.

ABSTRACT: New onset refractory status epilepticus (NORSE), including its subtype with a preceding febrile illness known as febrile infection-related epilepsy syndrome (FIRES), is one of the most severe forms of status epilepticus. The exact causes of NORSE are currently unknown, and there is so far no disease-specific therapy. Identifying the underlying pathophysiology and discovering specific biomarkers, whether immunologic, infectious, genetic, or other, may help physicians in the management of patients with NORSE. A broad spectrum of biomarkers has been proposed for status epilepticus patients, some of which were evaluated for patients with NORSE. Nonetheless, none has been validated, due to significant variabilities in study cohorts, collected biospecimens, applied analytical methods, and define

SUBMITTER: Hanin A 

PROVIDER: S-EPMC10756682 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature