Clinical, oral immunological and microbiological shifts during and after pregnancy.

ABSTRACT:

Objectives

Physiological changes and shifts in the oral microbiota composition during pregnancy may affect the maternal immune system. Uncomplicated pregnancy is associated with a T-helper (Th) 2 predominant cytokine regulation (anti-inflammatory), while oral health deterioration during pregnancy is reflected by severe gingival inflammation, a primarily Th1 cytokine phenotype (pro-inflammatory), and oral microbiome alterations. This prospective observational study aimed to evaluate Th cytokine shifts and changes in the oral microbiota composition in saliva of women before and after birth.

Material and methods

Saliva (n = 96) was collected before and 6 months after birth, and medical, oral health, and periodontal status were assessed. In a multiplex immunoassay, 10 cytokines

SUBMITTER: Meric P 

PROVIDER: S-EPMC10756889 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature