Role of hyperglycemia in cystic fibrosis pulmonary exacerbations.

ABSTRACT:

Background

Hyperglycemia could affect treatment response during cystic fibrosis (CF) exacerbations. We aimed to evaluate the prevalence and associations of hyperglycemia with exacerbation outcomes. We also evaluated feasibility of continuous glucose monitoring (CGM) during exacerbations.

Methods

The STOP2 study assessed efficacy and safety of different durations of intravenous antibiotics for CF exacerbations. We conducted a secondary data analysis of random glucose levels measured as part of clinical care during exacerbations. A small subset of participants also underwent CGM per research protocol. The associations between hyperglycemia, defined as random glucose ≥140 mg/dL, and changes in weight and lung function with exacerbation treatment were evaluated with linear regre

SUBMITTER: Merjaneh L 

PROVIDER: S-EPMC10756929 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature