Protein Biomarkers and Major Cardiovascular Events in Older People With Advanced CKD: The European Quality (EQUAL) Study.

ABSTRACT:

Rationale & objective

Cardiovascular disease is the leading cause of morbidity and mortality in chronic kidney disease (CKD). We investigated 184 inflammatory and cardiovascular proteins to determine their potential as biomarkers for major cardiovascular events (MACEs).

Study design

The European Quality (EQUAL) is an observational cohort study that enrolled people aged ≥65 years with an estimated glomerular filtration rate ≤20 mL/min/1.73 m².

Setting & participants

Recruited participants were split into the discovery (n = 611) and replication cohorts (n = 292).

Exposure

Levels of 184 blood proteins were measured at the baseline visit, and each protein was analyzed individually.

Outcome

MACE.

Analytical approach

Cox proportional hazard m

SUBMITTER: Hayward SJL 

PROVIDER: S-EPMC10757029 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature