Genetically determined telomere length and its association with chronic obstructive pulmonary disease and interstitial lung disease in biobank Japan: A Mendelian randomization study.

ABSTRACT:

Importance

Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) have been linked to shorter telomere length (TL). While understanding this association has critical clinical implications for respiratory diseases, previous studies exploring these associations were conducted in European populations. The present study aims to investigate this relationship in an Asian population.

Objective

To examine the causal relationship between leukocyte TL and COPD and ILD in an Asian population.

Design

Setting, and Participants: We used a genome-wide association study summary statistics-based two-sample Mendelian randomization (MR) design to investigate the association between leukocyte TL, genetically predicted by nine single-nucleotide polymorphisms and

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10757031 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature