Development and validation of a novel nomogram predicting clinically significant prostate cancer in biopsy-naive men based on multi-institutional analysis.

ABSTRACT:

Background

Prediction of clinically significant prostate cancer (csPCa) is essential to select biopsy-naive patients for prostate biopsy. This study was to develop and validate a nomogram based on clinicodemographic parameters and exclude csPCa using prostate-specific antigen density (PSAD) stratification.

Methods

Independent predictors were determined via univariate and multivariate logistic analysis and adopted for developing a predictive nomogram, which was assessed in terms of discrimination, calibration, and net benefit. Different PSAD thresholds were used for deciding immediate biopsies in patients with Prostate Imaging-Reporting and Data System (PI-RADS) 3 lesions.

Results

A total of 932 consecutive patients who underwent ultrasound-guided transperineal cogniti

SUBMITTER: Ge Q 

PROVIDER: S-EPMC10757090 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature