Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease.

ABSTRACT:

Aim

The gut microbiota has been reported to be associated with acute graft-versus-host disease (aGvHD) in hematopoietic stem cell transplantation (HSCT). Dynamic surveillance of the microbiota is required to understand the detailed pathogenesis involved in the process of aGvHD.

Methods

Fecal samples were collected prospectively at four timepoints, including pre-HSCT (T1), graft infusion (T2), neutrophil engraftment (T3), and 30 days after transplantation (T4). Fecal samples were profiled by 16S ribosomal RNA gene sequencing to assess the microbiota composition.

Results

From the T1 to T4 timepoint, the diversity of the gut microbiota decreased, and the dominant species also changed, with a decrease in the obligate anaerobic bacteria and a shift toward a "pathogenic com

SUBMITTER: Qi L 

PROVIDER: S-EPMC10757094 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature