Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer.

ABSTRACT:

Background

Helicobacter pylori is a gastric pathogen that is responsible for causing chronic inflammation and increasing the risk of gastric cancer development. It is capable of persisting for decades in the harsh gastric environment because of the inability of the host to eradicate the infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But the effectiveness of treating H. pylori has significantly decreased due to widespread antibiotic resistance, including an increased risk of gastric cancer. The small interfering RNAs (siRNA), which is capable of sequence-specific gene-silencing can be used as a new therapeutic approach for the treatment of a variety of such malignancies. In the current study, we rationally designed two

SUBMITTER: Reza MN 

PROVIDER: S-EPMC10757103 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature