The loss of neoantigens is an important reason for immune escape in multiple myeloma patients with high intratumor heterogeneity.

ABSTRACT:

Objectives

Intratumor heterogeneity (ITH) is an important factor for clinical outcomes in patients with multiple myeloma (MM). High ITH has been proven to be a key reason for tumor immune escape and treatment resistance. Neoantigens are thought to be associated with ITH, but the specific correlation and functional basis for this remains unclear.

Methods

We study this question through the whole-exome sequencing (WES) data from 43 high ITH newly diagnosed MM patients in our center. Mutant allele tumor heterogeneity (MATH) was conducted to quantify ITH. The cutoff value for high intratumor heterogeneity was determined by comparing MATH of different kinds of tumors. NeoPredPipe was performed to predict neoantigens and binding affinity.

Results

Compared to other tumors, MM

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10757111 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature