Clinical characteristics and prognostic factors analysis of core binding factor acute myeloid leukemia in real world.

ABSTRACT:

Background

Chromosomal translocations involving core binding factor (CBF) genes account for 15% of adult acute myeloid leukemia (AML) cases in China. Despite being classified as favorable-risk by European Leukemia Net (ELN), CBF-AML patients have a 40% relapse rate. This study aims to analyze clinical characteristics and prognosis of CBF-AML, compare its subtypes (inv(16) and t(8;21)), and validate prognostic factors.

Methods

Retrospective analysis of 149 AML patients (75 CBF-AML, 74 non-CBF) at Peking University First Hospital (March 2012-March 2022).

Results

CBF-AML patients have significantly lower disease-free survival (DFS) (p = 0.005) and higher non-relapse mortality (NRM) (p = 0.028) compared to non-CBF AML. inv (16) and t(8;21) show distinct co-occurring gene

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC10757144 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature