Dataset Information

Apatinib added when NSCLC patients get slow progression with EGFR-TKI: A prospective, single-arm study.

ABSTRACT:

Background

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) acquired resistance was an inevitably events in NSCLC treatment.

Aims

Intending to overcome the acquired resistance of EGFR-TKI.

Materials & methods

A clinical trial was, we enrolled 12 patients who were slowly progressing on first-generation EGFR-TKI, and added apatinib when the patients got slow progression.

Results

Seven patients were included in the efficacy analysis. The median PFS2 of apatinib combined with EGFR-TKI was 8.2 months (95% CI, 7.3 m-NA), and the total PFS reached 20.9 months (95% CI, 17.3 m-NA) when plus PFS1. All the adverse events were manageable. The median PFS was significantly longer for circulating tumor DNA (ctDNA)-cleared patients (8.4 months; 95% CI, 8.2-NA) than for those ctDNA not cleared (7.1 months; 95% CI, 6.9-NA) (p = 0.0082).

Discussion

The addition of apatinib did improve the duration of first-generation EGFR-TKI use, and the duration was better than the first-line use of third-generation EGFR-TKI.

Conclusion

The addition of apatinib when the patients got slow progression after initial EGFR-TKI therapy may be a good treatment option and the side effects are controllable. It is possible to monitor treatment efficacy using ctDNA.

SUBMITTER: Liu M

PROVIDER: S-EPMC10757148 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Apatinib added when NSCLC patients get slow progression with EGFR-TKI: A prospective, single-arm study.

Liu Minghui M Li Xin X Zhang Hongbing H Ren Fan F Liu Jinghao J Li Yongwen Y Dong Ming M Zhao Honglin H Xu Song S Liu Hongyu H Chen Jun J

Cancer medicine 20231130 24

<h4>Background</h4>Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) acquired resistance was an inevitably events in NSCLC treatment.<h4>Aims</h4>Intending to overcome the acquired resistance of EGFR-TKI.<h4>Materials & methods</h4>A clinical trial was, we enrolled 12 patients who were slowly progressing on first-generation EGFR-TKI, and added apatinib when the patients got slow progression.<h4>Results</h4>Seven patients were included in the efficacy analysis. The median PFS ...[more]

PMID: 38033095

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Dataset Information

Apatinib added when NSCLC patients get slow progression with EGFR-TKI: A prospective, single-arm study.

Background

Aims

Materials & methods

Results

Discussion

Conclusion

Publications

Apatinib added when NSCLC patients get slow progression with EGFR-TKI: A prospective, single-arm study.

Similar Datasets

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